Opportunity is a function of knowledge that can be combined.
Everything is interconnected, everything has some effect on everything else.
You can understand these effects by understanding the associated knowledge. The better understanding of the knowledge, the better understanding of the effects.
When you understand the effects, there is the potential to create an outcome based on those effects. This is opportunity.
A great example of this is the person who understood sawmills and the waste in the form of sawdust and who understood fires and firewood. He understood the effects each of these pieces of knowledge could have and he invented the firelogs made out of waste sawdust.